An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages
نویسندگان
چکیده
Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SRA), hence promoting tumor progression. We demonstrated that SRA can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013